Pathogenetic relationship between kidney pathologies and the microcirculatory capillary layer in dogs under the influence of Babesia canis

With babesiosis in dogs, the capillary network is especially strongly affected due to stimulation of hemostasis system and development thrombus formation microvasculature. Acute renal failure even death animals are caused by shock phenomena syndrome disseminated intravascular coagulation. Clinical, laboratory (hematological, biochemical, coagulometric, hemodynamic, enzyme immunoassay) methods research were conducted. Dogs with have fever, anemia, hemoglobinuria, hematologically established systemic inflammation, thrombotic condition. Hemodynamic parameters determine state shock, which dynamics becomes decompensated irreversible. The appearance poikilocytes blood sick dogs indicates significant metabolic disorders their body. coagulogram reveals Syndrome markers significantly changed a trend increase during nephropathy. In addition, uremia, hyperuricemia, hyperkalemia, hyponatremia, hyperphosphatemia, creatininemia found reliable indicators an acute form glomerulonephritis progressive failure. According study general biochemical status animals, hepatopathy hepatitis pancreatitis, intoxication established. our findings: spontaneous babesiosis, developed nephropathy, has two clinical stages: hemoglobinuria oliguria/anuria. pathogenetic basis for coagulation response influence pathogen, causes forming vicious circle shock. Under such conditions, increases eventually leads animal. studied data will contribute expansion conceptual understanding pathogenesis canine leading role complications kidney